Staff Biography
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JOHN W. SIXBEY, M.D.Co-Director, Center for Molecular and Tumor Virology, LSUHSC-Shreveport www.lsuhscmicrobiology.com/sixbey.htm Feist-Weiller Cancer Center |
ContactPhone: (318) 675-4272 Team Membership |
Education / Honors / Board Certifications / Professional Associations / Research / Publications
Education / Professional Experience
Co-Director, Center for Molecular and Tumor Virology, LSUHSC, Shreveport, LA 2003-present
Associate Director, Feist-Weiller Cancer Center, LSUHSC, Shreveport LA 1998-present
Professor, Department of Microbiology & Immunology; Infectious Diseases Section, Department of Medicine, LSUHSC 1998-present
Program Leader, Viral Oncogenesis and Tumor Immunology, St. Jude Children’s Research Hospital, Memphis TN 1996-1998
Professor, Department of Pediatrics and Department of Pathology, College of Graduate Health Sciences, University of Tennessee College of Medicine, Memphis TN 1991-1998
Member and Attending Physician, Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis TN 1983-1998
Member, Department of Virology and Molecular Biology, St. Jude Children’s Research Hospital, Memphis TN 1983-1998
Infectious Diseases Fellowship, 1980-83, University of North Carolina Lineberger Comprehensive Cancer Center
Medicine Residency, 1977-80, University of Maryland Hospital
M.D., 1977, University of Arkansas for Medical Sciences
B.A., Political Science, 1966, University of Maryland at College Park
Honors and Awards
Editorial Board, Journal of Virology, 2005-present
Editorial Board, Virus Research, 2005-present
Editorial Board, Journal of Infectious Diseases, 2006-present
Member, Experimental Virology Study Section, National Cancer Institute, 1996-1999
Member, National Institutes of Health Reviewers Reserve, 1992-1996
Governing Board, International Association for Research on Epstein-Barr Virus, 1994-1998
Fellowship:
Elected Fellow, Infectious Diseases Society of America
American Social Health Association Awarded Infectious Diseases Fellowship, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill NC 1980-1983
Board Certifications:
Diplomate, American Board of Internal Medicine 1981
Professional Associations:
Infectious Diseases Society of America
American Federation for Medical Research
American Society of Microbiology
Sigma Xi
International Association for Research on Epstein-Barr Virus
American Society for Virology
Research Interest
EBV Pathogenesis
The notion that viruses may be responsible for initiation of disease, yet fail to persist in affected tissues, is frequently raised in the context of chronic diseases of unknown etiology. We are investigating Epstein-Barr virus pathogenesis and the sporadic nature of its association with human cancers: gastric carcinoma, head and neck squamous cell carcinoma, Burkitt’s lymphoma, Hodgkin’s lymphoma, leiomyosarcoma, and central nervous system lymphoma. We are testing models of EBV pathogenesis more compatible with such an unpredictable association of virus with tumor that include a temporal sequence of 1) cell transformation; 2) EBV infection of a pre-existing neoplasm; 3) EBV driven tumor progression; 4) viral redundancy and loss from infected tissue.
Selected Publications
Chodosh, J., V. Holder, Y. J. Gan, A. Belgaumi, J. Sample, and J. W. Sixbey. 1998. Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth transformed cell phenotype. J. Infect. Dis. 177:1194-1201.
Srinivas, S., J. Sample, and J. W. Sixbey. 1998. Spontaneous loss of viral episomes accompanying Epstein-Barr virus reactivation in a Burkitt lymphoma cell line. J. Infect. Dis. 177:1705-1709.
Chodosh, J., Y-J. Gan, V. P. Holder, J. W. Sixbey. 2000. Patterned entry and egress by Epstein Barr virus in polarized CR2-positive epithelial cells. Virology. 266:387-396.
Gan, Y. J., B. I. Razzouk, T. Su, J. W. Sixbey. 2002. A defective, rearranged Epstein-Barr virus genome in EBER-positive and –negative Hodgkin’s disease. Am. J. Pathol. 160:781-6.
Moody, C. A., R. S. Scott, T. Su, J. W. Sixbey. 2003. Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence. J. Virol. 77:8555-61.
Wagner H. J., R. S. Scott, D. Buchwald, J. W. Sixbey. 2004. Peripheral blood lymphocytes express recombination-activating genes (RAG) 1 and 2 during Epstein-Barr virus (EBV)-induced infectious mononucleosis. J. Infect Dis. 190:979-984.
Stewart S, C. W. Dawson, K. Takada, J. Curnow, C. A. Moody, J. W. Sixbey, L. S. Young. 2004. Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-κB transcription factor pathway. Proc Natl Acad Sci USA. 101:15730-15735.
Bollard C. M., L. Aguilar, Straathof KC, B. Gahn, M. H. Huls, A. Rousseau, J. Sixbey, M. V. Gresik, G. Carrum, M. Hudson, D. Dilloo, A. Gee, M. K. Brenner , C. M. Rooney, H. E. Heslop. 2004. Cytotoxic T lymphocyte therapy for EBV-positive Hodgkin’s disease. J. Exp Med. 200:1623-1633.
Cerimele F, T. Battle T, R. Lynch, D. A. Frank, E. Murad, C. Cohen C, N. Macaron, J. Sixbey, K. Smith, R. S. Watnick, A. Eliopoulos, B. Shehata, J. L. Arbiser. 2005. Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr virus (EBV)-positive versus EBV-negative Burkitt’s lymphoma. Proc Natl Acad Sci USA. 102:175-179.
Moody C. A., R. S. Scott, N. Amirghahari, C. A. Nathan, L. S. Young, C. W. Dawson, J. W. Sixbey. 2005. Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. J. Virol. 79:5499-5506.