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Staff Biography

 

Cherie-Ann O. Nathan MD, FACS

Professor and Vice-Chairman
Department of Otolaryngology/Head and Neck Surgery, LSUHSC

Director of Head & Neck Surgical Oncology and Cancer Research Feist-Weiller Cancer Center Shreveport

Contact

Phone: (318) 675-6262
Fax: (318) 675-6260
CNatha@lsuhsc.edu

Teresa Harris
(318) 813-1427

Team Membership

Head And Neck Cancer

Upper Aerodigestive Tract Group
Translational Control Group
Clinical Trials Group

Gene Therapy Group

 

Clinical Services / Education / Honors / Board Certifications / Professional Associations / Research / Publications

 

Clinical and Research Expertise

Dr. Cherie-Ann Nathan’s clinical interests include head and neck cancer surgery of the  oral, oropharyngeal , laryngeal , hypopharyngeal, nasal, paranasal sinuses and salivary gland cancers. She has a special interest in thyroid and parathyroid diseases. In addition she has a particular interest in voice disorders from both organic and functional causes and has a botox clinic for spasmodic dysphonia patients after ruling out lesions of the vocal cord. Along with neurosurgery she treats cancers of the skull base especially that of the anterior cranial fossa. She heads the Tumor Board, a weekly multi-disciplinary conference to discuss the care of all cancer patients. She has a strong translational research program with many novel projects that have moved from the bench to the bedside (see details below). As a result she has approximately 100 publications and has presented at over a 100 meetings.
 

Education / Professional Experience

1979-1981 Premedical; University of Bombay, Jai-Hind College H.S.C., Sciences
1981-1987 Medical School; University of Bombay, T.N.M.C., M.B.B.S. (M.D.)
1987-1988 Residency in Otolaryngology at University of Bombay, T.N.M.C.
1988-1989 Post-Doctoral Research Fellow in Otolaryngology-Head and Neck Surgery at Johns Hopkins University School of Medicine.
1989-1990 Internship in General Surgery at Butterworth Hospital / Michigan State University.
1990-1994 Residency in Otolaryngology- Head and Neck Surgery at University of California, San Diego.
1994-1995 Clinical Instructor and Head and Neck Fellow in Division of Otolaryngology/Head & Neck Surgery at University of California, San Diego

 

Honors and Awards

FWCC’s Otolaryngologist, Cherie- Ann Nathan is a talented surgeon as well as an innovative researcher. Her ideas on molecular analysis of surgical margins have led to the receipt of a large grant from the NCI (National Cancer Institute). A clinical trial is being conducted as a result of these studies, which have put Dr. Nathan’s program at the forefront of molecular targeted therapy for head and neck cancer nationally.

The Cherie-Ann Nathan, M.D. Endowed Professorship in Otolaryngology/Head and Neck Surgery was initiated by a grateful patient who made a generous donations. This professorship will serve as a perpetual tribute to Dr. Nathan’s unwavering devotion to her patients. Donors have given more than $30,000 which is over half the fundraising
goal. Once $60,000 is raised locally, the LSU Health Sciences Foundation will be able to leverage private dollars with $40,000 in matching funds from the Louisiana Board of Regents to establish a $100,000 endowment. Only the interest generated from the funds will be expended leaving the principle to continue Dr. Nathan’s legacy forever.

CADBURY'S BEST ALL-AROUND STUDENT AWARD   (1978)

  1. DISTINCTION in the Premedical Examination (1979)
  2. C.A.B.  INSTITUTION AWARD   "The Best Student of 1979"
  3. HONORS in Physiology at the University of Bombay (1982)
  4. T.N. MEDICAL COLLEGE AWARD "The Best Student of 1983"
  5. FIRST in Surgery Practical at the University of Bombay Final MBBS Examination (1985)
  6. MENINO DESOUZA AWARD   "The Best Student of 1986"
  7. RHODES Scholarship finalist  (1987)
  8. INLAKS Scholarship for Outstanding Student-Scientist to Johns Hopkins University School of Medicine (1988-1989)
  9. AAO-HNS Cherry Blossom Travel Award (1991)
  10. AAOA Travel Award (1993)
  11. Nominated for “Woman Who has Made a Difference to Shreveport” (1998)
  12. AACR Travel Award for Methods in Clinical Cancer Research (1998)
  13. Stratford’s WHO’s WHO (1999)
  14. National Registry WHO’s WHO (2000)
  15. WHO’s WHO in America Marquis Directory (2000-present)
  16. American Academy of Otolaryngology/HNS National Honors Award (2001)
  17. WHO’s WHO of American Women (2002)
  18. American Registry of Outstanding Professionals (2002)
  19. Guide to America’s Top Physicians (2003-present)
  20. WHO’s WHO in Science and Engineering (2003-2008)
  21. International Health Profession Scientist of the year (2004)
  22. International Biographical Centre of Living Legends (2004)
  23. WHO's WHO in Medical Sciences Education (2005)
  24. 60th Diamond Edition Marquis WHO’s WHO in America
  25. LSUHSC Team Recognition Award 2005 , 2007
  26. VIP Member in the Continental Who's Who registry of National Business Leaders 2005:Fellow Life Time Publication
  27. Empire Who’s Who Among Executives and Professionals in Medicine & Healthcare& Honor’s Edition
  28. Marquis WHO’s WHO in Medicine and Healthcare (2006, 2007)
  29. Alpha Omega Alpha Honor Medical Society as Faculty Member 2006
  30. Top 100 Health Professionals International Biographical Center 2006
  31. Metropolitan Who’s Who Professional Honor Society 2006
  32. LSUHSC Team Recognition Award 2007
  33. Madison’s WHO’s WHO for Executive Professionals 2007-2008
  34. Biltmore’s WHO’s WHO Among Executives and Professional Women and 2007 Honors Edition
  35. Nominated for the Collegium ORLAS 2007

Board Certifications

Otolaryngology/Head and Neck Surgery

Professional Associations

NATIONAL COMMITTEES

  1. National Committee of ACS for Biomarkers in HNSCC- 1999;
  2. Young Academicians Committee for the National SUO-1998-Present
  3. Program Committee for the Southern Section of the Triologic Society
  4. Education Committee for AAOI-2001-Present
  5. American Head and Neck Society: Education Committee-2001-2004
  6. Delegate to the Louisiana State Medical Society-2001
  7. Southwest Oncology Group/Head and Neck Committee-2003-Present
  8. American Head and Neck Society: Research Committee-2003-Present
  9. Society of University Otolaryngologist: Resident Education Hours-2004
  10. Head and Neck Surgery and Oncology Committee-2005-2008
  11. Board of Directors Shreveport Medical Society-2005
  12. Executive Committee AAOI-2005
  13. Program Committee 7th International Conference on Head and Neck Cancer-2006
  14. Publications Committee for American Head and Neck Society-2007- present
  15. Nominated to Previously-untreated Locally Advanced Task Force of the Head and Neck Cancer Steering Committee of the NCI-2007-present

PROFESSIONAL SOCIETIES

  1. American Academy of Otolaryngology-Head and Neck Surgery
  2. American Head and Neck Society
  3. AMA
  4. Southern Medical Society
  5. Louisiana State Medical Society
  6. Southwest Oncology Group
  7. Society of University Otolaryngologists-Head and Neck Surgeons
  8. American Association for Cancer Research
  9. American College of Surgeons
  10. Member of the Triologic Society
  11. North American Skull Base Society

Research Interest

Pharmacological inhibitors of mTOR. Our laboratory focuses on the use of pharmacologic inhibitors of mammalian target of rapamycin (mTOR) for the treatment of head-and-neck cancer. Inhibition of mTOR by rapamycin analogues inhibits phosphorylation of 4E-BP1 and sequesters eIF4E with 4E-BP1 decreasing translation of mRNAs involved in tumor progression. Our laboratory is determining various adjuvant therapeutic modalities for patients with molecular positive Akt/mTOR positive margins. To determine if rapamycin analogues can potentially be used as adjuvant therapy for patients with mTOR pathway-positive margins, we are elucidating upstream and downstream effectors of the mTOR pathway in head-and-neck squamous cell carcinoma (HNSCC) patients with mTOR overexpressing margins.

Radiation Therapy. Radiotherapy activates cytotoxic cellular mechanisms through the induction of DNA damage and activating pro-apoptotic ASK1/JNK pathway, but at the same time g-radiation further enhances anti-apoptotic PI3K/AKT/mTOR pathway. Rapamycin analogues can effectively inhibit signal transduction downstream from mTOR, attenuating cap-dependent translation of many pro-oncogenic and pro-survival factors. A novel therapeutic approach using a combination of radiation therapy and mTOR inhibition is being investigated for the potential role of mTOR inhibiting agents in the sensitizing of HNSCC tumor to radiation therapy.

PET-imaging. Inoculation of head-and-neck cancer cells subcutaneously into a small surgical incision is used to generate minimal residual disease (MRD) murine model. Functional imaging using 18F deoxy-3”-fluorothymidine (FLT), a proliferation-based tracer, has been emerging as a promising tool to evaluate tumor proliferation activity. Using MRD model we are conducting a comparative study on the usage of 18F fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) and FLT-PET imaging modalities for the early post-surgical diagnostics of head-and-neck cancer recurrence.

Chemoprevention. We are also interested in chemoprevention studies with natural products. Curcumin, isolated from turmeric, has been implicated as a powerful therapeutic in a variety of human cancers because of its ability to induce apoptosis and is currently undergoing clinical trials for colon, skin, pancreatic, and hematologic cancers, although its effect on oral HNSCC has been limited for in vivo benefit due to low gastrointestinal absorption. The overall goal of this study is to determine whether curcumin can be used as a chemopreventive agent in SCC, and whether local or systemic curcumin treatment affects tumor formation, progression and recurrence. Our goal is to conduct clinical trials with curcumin in HNSCC patients especially those at a high risk of recurrence or even initial malignancy with the goal of decreasing incidence and recurrence rates. Up to 50% of patients develop recurrence of HNSCC therefore preventing any of the steps of neoplastic transformation, from initiation to promotion to progression is a promising strategy.

Major Research Interests:

  • Head-and-neck cancer
  • Squamous carcinoma
  • PI3K/Akt/mTOR pathway
  • mTOR inhibitors
  • eIF4E
  • curcumin
  • chemoprevention
  • radioresistance
  • radiosensitization

Research Projects

Project 1, an exploratory biomarker trial of temsirolimus in subjects with newly diagnosed advanced stage squamous cell carcinoma of the head and neck.At the clinical level, the Otolaryngology /Head and Neck Surgery Dept. at LSUHSC, Shreveport with the Feist-Weiller Cancer Center is conducting an exploratory biomarker trial of mTOR inhibitors in subject with newly diagnosed advanced stage HNSCC. The effects of mTOR inhibitor temsirolimus on the phosphorylation state of key proteins in the mTOR pathway in tumor and peripheral blood mononuclear cells (PBMC) of HNSCC patients are being evaluated. Significant inhibition of the mTOR pathway was noted in both tumors and PBMCs of HNSCC with minimal side effects. mTOR inhibitors can potentially be used as adjuvant therapy for patients with MRD and PBMCs are potential surrogate markers in this setting.

Project 2, prognostic markers for head-and-neck cancer recurrence. Multi-institutional trial: molecular analysis of margins. We have determined that the proto-oncogene eIF4E is overexpressed in 100% of HNSCC. A single institutional NIH/NCI funded study showed that eIF4E overexpression in histologically “tumor-free” surgical margins results in a significant decrease in disease free interval compared to patients with eIF4E-negative margins. Now in collaboration with Dr. Koch’s group from Johns Hopkins we are conducting multi-institutional trial to test whether overexpression of the Akt/mTOR/eIF4E pathway in the histologically “tumor-free” mucosal surgical margins of resectable HNSCC patients is an independent prognostic marker for cancer recurrence.

Project 3, radiosensitizing effects of mTOR inhibitors in head-and-neck cancer. Preliminary results of our animal studies suggest that mTOR inhibitors display potential better radiosensitizing properties than conventional radiosensitizing agent cisplatin, and have less toxic side effects.

Project 4, chemoprevention of head-and-neck cancer using natural product (curcumin). We are studying whether curcumin can be used as a chemopreventive agent in head-and-neck squamous cell carcinoma with a goal of decreasing incidence and recurrence rates.

Specialized Techniques/Procedures

  1. Cell culture, Cell proliferation assay, cytotoxicity assay.
  2. Immunohistochemistry.
  3. Western blotting.
  4. Protein, RNA and DNA extraction. 
  5. PCR, RT-PCR and Real-Time PCR.
  6. Flow Cytometry both for cell cycle and apoptosis.
  7. Pharmacokenitic studies.
  8. Surgical procedure in general and techniques for Minimal Residual Animal Model (MRD).
  9. Radiation studies in vivo and in vitro.
  10. Transfection, generation of stably transfected cell lines.
  11. FDG- and FLT-PET in animal cancer models.

Publications

(maiden name Menezes)

Book Chapters

    1. DeSouza C, Menezes CO, Parthasarathy, R: Sleep Apnea: In Textbook of the Ear, Nose & Throat: Ed. by Chris DeSouza, Marcos Goycoolea, Carlos Ruah. Orient Longman, Chap. 5.8, p. 472-474, 1995.
    2. Stucker FJ, Nathan CO. Cutaneous Malignancy: In Head & Neck Surgery-Otolaryngology, 2nd edition. Ed. by Byron J.Bailey, Robert Kohut, Harold Pillsbury, Eugene Tardy. J.B. Lippincott Company, Chap.101, p. 1415-1438, 1999.
    3. DeSouza C., Nathan CO., Stucker FJ. Tracheostomy: In A Textbook of Pediatric Otolaryngology Head and Neck Surgery. Ed. by Chris DeSouza, James Stankiewicz, Phillip Pellitteri: Singular Publishing Co, San Diego; Chap. 8, p. 103-110,1998.
    4. Nathan CO, Pate W, Stucker FJ. Alloplasts in Facial Reconstruction: In Surgical Reconstruction of the Face and Anterior Skull Base Ed. by Maniglia, Stucker and Stepnick: W.B. Saunders Co. Chap 25: p. 311-324, 1999.
    5. Nathan CO, De Souza C, Stucker FJ. Alloplastic Implants in Rhinoplasty: In Septorhinoplasty-Reconstructive, Functional, and Aesthetic Ed. by Maniglia.
    6. Nathan CO, Chakradeo V. Robotics in Otolaryngology: In Head and Neck Surgery Ed by DeSouza C, Gady-Har El, Nuss D, Fazekas M, Nathan C, Stucker F.
    7. Head and Neck Surgery: Editors, DeSouza C, Gady-Har El, Nuss D, Fazekas M, Nathan C, Stucker F (in preparation)

Publications and Published Proceedings

    1. Ilabachie K, Nathan CO,  Morgan M, Ampil F, Caldito G. Return of vocal cord movement: an independent predictor of response to non-surgical management of laryngeal cancers.  Laryngoscope; 117(11):1925-1929, 2007.
    2. Nathan CO, Amirghahari N, Rong X, Giordano A, Sibley D, Nordberg M, Glass J, Agarwal A, Caldito G. mTOR Inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer. Cancer Res.; 67(5):2160-8, 2007.
    3. Nathan CO, Mills G, Rong X, Drummond D, Amirghahari N, Aggarwal A, Rong Y, Glass J, Lian T. An exploratory biomarker trial of an mTOR inhibitor in subjects with newly diagnosed advanced stage HNSCC: Proceedings AACR Supplement, Volume 48, page 42, 2007
    4. Ampil F, Nathan C, Sangster G, Lian T, Shukla D, Aultman D. Combined therapy for thyroid cancer invading the esophagus. Short Communication:  Journal of Radiotherapy in Practice; 6: 1-2, June 2007
    5. Ampil F, Nathan CO, Lian C, Caldito G, Milligan E. Total Laryngectomy and T3-T4 Laryngeal cancer without other adverse histopathology. Otolaryngol Head Neck Surg.;136(2):296-300, 2007.
    6. Ye G, Burton G, Nathan CO, Ampil F. Squamous Cell Carcinoma of Oral cavity following Breast Cancer Treatment. Southern Medical Journal Letters to the Editor. 99 (10):1-2, 2006
    7. Nathan CO, Chakradeo V, Malhotra K, D’Agostino H, Patwardhan R. The Voice-Controlled Robotic Assist Scope Holder AESOP for the endoscopic approach to the sella. Skull Base: An Interdisciplinary Approach, 16(3): 123-131, 2006.
    8. DeBenedetti A, Mathis J, Williams J, Nathan CO. Cancer-specific Targeting of an Adenovirus-delivered Herpes Simples Virus Thymidine Kinase Suicide Gene Using Translational Control. The Journal of Gene Medicine 8(9): 1105-1120, 2006
    9. Kumar V, Blachon B, Gu Xin, Scarborough Nathan CO, Subashini Y. Anaplastic Thyroid cancer and Hyperthyroidism. Endocr Pathol.16(3):245-50, 2005
    10. Lee M, Ramaswamy M, Lilien D, Nathan CO. Unilateral Vocal Cord Paralysis Causes Contralateral False Positive PET Scans of the Larynx. Ann Otol Rhinol Laryngol. Mar:114(3):202-6, 2005.
    11. McDuffie C, Morgan M, Armstrong C, Nathan CO. Electrical Stimulation in Post-Irradiated Head and Neck SCCA. Otolaryngology-Head and Neck Surgery; 133: P101, 2005
    12. Nathan A, Turakhia A, Amirghahari N, Nathan C, Klimstra W, Katherine R. Sindbis Virus as a Novel Oncolytic Vector for Virotherapy of Head and Neck Cancer. Otolaryngology-Head and Neck Surgery; 133: P 97, 2005.
    13. Chakradeo V, Malhotra K, Lee M, Nathan CO. Navigational Surgery with Voice Controlled Robotic Assist for Endoscopic Approach to the pituitary. Otolaryngology-Head and Neck Surgery; 133: P153, 2005.
    14. Amirghahari N, Sibley D, Rong X, Caldito G, Nathan CO. Growth Inhibitory and pharmacodynamic effects of CCI-779, an mTOR inhibitor, in a preclinical microscopic residual disease model of head and neck squamous carcinoma. 96th Annual AACR Meeting proceedings Vol.46, pg107, 2005.
    15. Moody, CA, Scott RS, Amirghahari N, Nathan CO, Young LS, Dawson CW, Sixbey JW. Modulation of Cell Growth Regulator mTOR by Epstein-Barr Virus-Encoded LMP2A. J Virol., 79(9):5499-506, 2005.
    16. McDuffie C, Amirghahari N, Caldito G, Thompson L, Lian T, Nathan CO. Predictive Factors for Posterior Triangle Metastasis: A Retrospective Review. Laryngoscope, 115(12): 2114-7, 2005.
    17. Nathan CO, Chakradeo V, Malhotra K. Voice-Controlled Robotic Assist for Endoscopic Approach to the Pituitary. Skull Base An Interdisciplinary Approach; 15 (1): pg 20, 2005
    18. Ampil F, Mills G, Heldmann M, Nathan CO. Head and Neck Cancer with Simultaneous Lung Cancer. J Louisiana SMS, 156:193-195, 2004.
    19. Pham J, Yin S, Morgan M, Stucker F, Nathan CO. Botulinum Toxin: A Helpful Adjunct to early resolution of Laryngeal granulomas. Journal of Laryngology and Otology; 118: 781-785, 2004.
    20. Nathan CO, Amirghahari N, Abreo F, Rong X, Caldito G, Jones ML, Zhou H, Smith M, Kimberly D, Glass J.  Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mTOR pathway. Clinical Cancer Research; 10: 5820-5827, 2004.
    21. Beal M, Chesson A, Garcia T, Stucker F, Nathan CO. Quantitative aspiration in patients with obstructive sleep apnea. Laryngoscope, 114 (6): 965-968, 2004.
    22. Sanders K, Pate W, Fowler M, Stucker F, Nathan CO. Aggressive Fibromatosis of the Parapharyngeal Space. Ear, Nose and Throat, 83 (4): 262-268, 2004.
    23. Ampil F, Nathan CO, Caldito G, Lian T, Aarstad R, Murty Krishnamsetty R. Total laryngectomy with postoperative radiotherapy:  A 14-year review. American Journal of Otolaryngology, 25:88-93, 2004.
    24. Amirghahari N, Sibley D, Rong X, Khodavandi M, Zhou H, Smith MB, Nathan CO. In vivo and in vitro effect of CCI-779 a rapamycin analogue on HNSCC. 95th Annual AACR Meeting proceedings Vol. 45, pg 850-851, 2004.
    25. Nathan CO, Amirghahari N, Rong Xiaohua R, Huijuan Z, Harrison L. eIF4E overexpression may confer radioresistance in a head and neck cancer cell line. Otolaryngology-Head and Neck Surgery, 131(2): 178, 2004.
    26. Nathan CO, Amirghahari N, Smith M, Rong X. Growth Inhibitory Effects of Rapamycin on Oral Cavity Squamous Cell Carcinoma. Otolaryngology-Head and Neck Surgery, 129(2): 216, 2003.
    27. Ampil F, Mills G, Nathan CO, Burton G, Mansour. Positive response of advanced oropharyngeal cancer and trismus to chemoradiation. South Med J, 96:316-317, 2003.
    28. Smith MB, Amirghahari N, Rong X, Shi R, De Bendetti A, Nathan CO. Correlation of mTOR activation in Head and Neck Cancer patients with eIF4E-positive margins. 94th Annual AACR Meeting proceedings Vol. 44, pg 678, 2003.
    29. Amirghahari N, Harrison Lynn, Rong X, Naumann I, Ampil F, Shi R, Glass J, Nathan CO. NS398 radiosensitizes a HNSCC cell line by possibly inhibiting radiation induced expression of COX-2. International Journal of Radiation Oncology, Biology, Physics, 57 (5): 1405-1412, 2003.
    30. Stucker FJ, Nathan CO and Lian T. Management experience in 142 cases of rhinophyma. Oto-Rhino-Laryngology, 1240: 615-619, 2003.
    31. Stucker, Nathan CO and Lian T. Cutaneous laser surgery in otolaryngology—head and neck surgery  Oto-Rhino-Laryngology, 1240:963-966, 2003.
    32. Stucker FJ, Nathan CO and Lian T. The use of autogenous cartilage grafts in revision nasal surgery  Oto-Rhino-Laryngology,1240: 611-614, 2003.
    33. Ampil FL, Mills GM, Caldito G, Burton G, Nathan CO, Aarstad R, Lian T, Stucker FJ, Hardin J. Induction chemotherapy followed by concomitant chemoradiation-induced regression of advanced cervical lymphadenopathy in head and neck cancer as a predictor of outcome. Otolaryngol Head Neck Surg, 126: 602-606, 2002.
    34. Nathan CO, Amirghahari N, Rice C, Abreo F, Shi R, Stucker F. Molecular analysis of surgical margins in HNSCC patients. Laryngoscope, 112: 2129-2140, 2002.
    35. Ampil F, Nathan CO, Lian T, Stucker F, Hardin J, Aarstad R. Salvage treatment of recurrent skin cancer of the midface. Am J Clin Oncol, 25: 580-582, 2002.
    36. Ampil F, Borski G, Nathan CO, Mulcahy G, Walker M, Chin H, Stucker F. Cavernous Sinus involvement by extramedullary plasmacytoma of the sphenoid sinus. An argument for the use of adjuvant chemotherapy. Leukemia and Lymphoma, 43(10): 2037-2040, 2002.
    37. Nathan CO, Dixie L, Stucker F. Voice-controlled robotic assist for endoscopic sinus surgery. Otolaryngology-Head and Neck Surgery, 127(2): 57, 2002.
    38. Fowler M, Nathan CO, Abreo F. Synovial Metaplasia, a specialized form of repair. A case report with literature review, Archives of Pathology and Laboratory Medicine, 126: 727-730, 2002.
    39. Ampil F, Veillon D, Nathan CO, Cotelingam J, Kottapurath K. CD23 Negative Lymphocytic Leukemia of the Tonsil: A Case Presentation. J La State Med Soc, 154:141-143, 2002.
    40. Ampil F, Caldito G, Ghali G, Nathan CO. Postoperative Radiotherapy for insecure or positive surgical margins in head and neck cancer. Oral and Maxillofacial Surgery, 425-429, 2002.
    41. Chandy B, Abreo F, Nassar R, Stucker F, Nathan CO. Expression of the proto-oncogene eIF4E in inflammation of the oral cavity. Otolaryngology Head and Neck Surgery, 126: 290-295, 2002.
    42. Goldfarb P, Biel M, Sayed-El, Hanna E, Hier M, Houck J, Klotch D, Nathan CO, Panje W, Robbins T, Shaw G, Jones V, Nasser J, Rice D, Vieira F. Treatment of recurrent Head and Neck Cancer utilizing electroporation with intralesional bleomycin: Long term survival. Proceedings of American Society of Clinical Oncology, 18: 340, 2002.
    43. Nathan CO, Amirghahari N, Rong X, Naumann I, Ampil F, Shi R, Glass J, Harrison L. Radiosensitizing and growth inhibition of a HNSCC cell line by a COX-2 inhibitor, NS398. 93rd Annual AACR meeting, Vol. 43, pg 483, 2002.
    44. Nathan CO, Leskov I, Lin M, Abreo F, Shi R, Hartman G, Glass J. COX-2 expression in dysplasia of the head and neck: correlation with eIF4E. Cancer, 92: 1888-1895, 2001.
    45. Ampil F, Nathan CO, Stucker FJ.  Complicated cirrhosis of the liver in patients with head and neck cancer. Otolaryngology Head and Neck Surgery, 125: 417-419, 2001.
    46. Nathan CO, Abreo FA, Shi R, Stucker FJ. Molecular Analysis of surgical margins with the proto-oncogene eIF4E. International Journal of Molecular Medicine, 8 (1): S10, 2001.
    47. Chandy B, Todd J, Stucker FJ, Lall C, Nathan CO. Pott’s puffy tumor and epidural abscess arising from dental sepsis: a case report. Laryngoscope, 111: 1732-1734, 2001.
    48. Ampil F, Mills G, Stucker F, Burton G, Nathan CO. Radical Combined treatment of locally extensive head and neck cancer in the elderly. American Journal of Otolaryngology, 22: 65-69, 2001.
    49. Lall C, Abreo F, Agrawal G, Nathan CO. Agnogenic Myeloid Metaplasia presenting with omental implants and ascites. Applied Radiology, 131: 40-43, 2001.
    50. Yin SG, Stucker FJ, Nathan CO. Clinical Application of Botulinum Toxin in Otolaryngology, Head and Neck Practice (brief review) J Louisiana SMS, 153(2): 92-97, 2001.
    51. Sanders K, Abreo F, Rivera E, Stucker F, Nathan CO. A Diagnostic and Therapeutic Approach to Paragangliomas of the Larynx. Archives of Otolaryngology/Head & Neck Surgery, 127: 565-569, 2001.
    52. Nathan CO, Sanders K, Abreo F, Nassar R, Glass J. Correlation of p53 and the proto-oncogene eIF4E in Larynx Cancers: Prognostic Implications. Cancer Research, 60: 3599-3604, 2000.
    53. DeFatta R, Nathan CO, De Benedetti A. Reducing the level of eIF4E with antisense RNA suppresses the oncogenic properties of Head and Neck Squamous Cell Carcinoma Cell Line. Laryngoscope, 110 (6): 928-933, 2000.
    54. Meyer M, Nathan CO. Reduced F- 18 Flurodeoxyglucose uptake within marrow after external beam radiation. Clinical Nuclear Medicine, 25 (4): 279-280, 2000.
    55. Borski G, Stucker, Grafton W, Nathan CO. Leiomyoma of the Trachea: A case report and a novel surgical approach. American Journal of Otolaryngology, 21(2): 119-121, 2000.
    56. Rice C, Abreo F, Shi R, Leskov I, Stucker F, Nathan CO. Expression of Matrix Metalloproteinase-9 and eIF4E co-localize in squamous cell carcinoma of the head and neck. Otolaryngology-Head and Neck Surgery, 123 (2); 2, 2000.
    57. Nathan CO, Harris, JP, Koutnouyan, HA, and Ryan A. Absence of mRNA Encoding Estrogen Receptor in the Cochlea of the Rat:  Current Awareness in Biomedicine: Steroid Receptors publication 2000.
    58.  McCaffrey J, Nathan CO, Levine P, Burkey B, Reiber M, Parke R, Hart J, Urken M, Stack B, Parey S, Shyr Y, Tarr C, Stawiasz, Lore J, Goldstein J, Sisson G, Day T. Head and Neck Cancer Screening: a multi-institutional effort. 5th International Conference on Head and Neck Cancer, 30: 49, 2000.
    59. Nathan CO, Harris, JP, Koutnouyan, HA, and Ryan A. Absence of mRNA Encoding Estrogen Receptor in the Cochlea of the Rat. Acta Otolaryngologica, 119: 853-857, 1999.
    60. Franklin S, Pho T, Abreo F, Nassar R, De Benedetti A, Stucker F, Nathan CO. Immunohistochemical Detection of the Proto-Oncogene eIF4E in Larynx and Hypopharynx Cancers. Archives of Otolaryngology/Head & Neck Surgery, 125:177-182, 1999.
    61. Nathan CO, Yin S, Stucker FJ. Botulinum Toxin: Adjunctive Treatment for Posterior Glottic Synechiae.  Laryngoscope, 109 (8): 855-857, 1999.
    62. Nathan CO, Franklin S, Abreo F, Nassar R, De Benedetti A, Glass J. Analysis of Surgical Margins with the Molecular Marker eIF4E: a prognostic factor in patients with Head & Neck Cancer. J Clin Oncol, 17 (9): 2909-2914, 1999.
    63. Nathan CO, Franklin S, Abreo F, Nassar R, De Benedetti A, Williams J, Stucker F. Expression of eIF4E during head & neck tumorigenesis: possible role in angiogenesis. Laryngoscope, 109 (8); 1253-1258; 1999.
    64. Sorrells D, Ghali G, De Benedetti A, Nathan CO, Li BD. Progressive Amplification and Overexpression of the Eukaryotic Initiation Factor 4E Gene in Different Zones of Head and Neck Cancers. J Oral Maxillofac Surg, 57(3):294-299, 1999.
    65. Sorrells D, Ghali G, Meschonat C, DeFatta R, Black D, Liu L, De Benedetti A, Nathan CO, Li BD. Competitive PCR to Detect eIF4E Gene Amplification in Head and Neck Cancer. Head & Neck, 21: 60-65, 1999.
    66. Franklin S, Pho T, Abreo F, Nassar R, De Benedetti A, Stucker F, Nathan CO. Immunohistochemical Detection of the Proto-Oncogene eIF4E in Larynx and Hypopharynx Cancers: selected for the Journal Club of Clinical Oncology, No. 11, 1999.
    67. Ampil FL, Mills GM, Nathan CO, Stucker FJ, Chin HW. Radical Combined treatment for locally extensive head and neck cancer in the elderly. Proceedings of American Association for Cancer Research, 40: pg 642, 1999.
    68. Goldfarb P, Biel M, Hanna E, Houck J, Klotch D, Nathan CO, Panje W, Robbins T, Shaw G, El-Sayed S, Hier M, Jones V, Nasser J, Rice D. A Phase II Study using electroporation and intratumoral bleomycin in patients with recurrent head and neck cancer. A safe and active treatment approach. Proceedings of American Society for Clinical Oncology, 18: 59, 1999.
    69. Ampil FL, Ghali GE, Nathan CO, Hardin JC. Effects of postoperative external beam irradiation after carotid artery stripping of nodal metastasis. J. Oral Maxillofacial Surgery, 56: 845-848, 1998.
    70. Ampil F, Ghali G, Hardin J, Hoasjoe D, Aarstad R, Nathan CO, Stucker FJ. Post-operative radiotherapy for nodal metastasis involving the carotid artery. The Oral Oncology, Vol. “V”: 239-341, 1998.
    71. Nathan CO, Franklin S, Abreo F, Nassar R. Immunohistochemical detection of the proto-oncogene eIF4E in surgical margins of Head and Neck Cancer patients may predict recurrence. Cancer Detection and Prevention, 22(1), 1998.
    72. Nathan CO, Franklin S, Abreo F, Stucker F. A Molecular Analysis of Surgical Margins using eIF4E in Head and Neck Squamous cell cancers. Otolaryngology-Head and Neck Surgery, 119: 84, 1998.
    73. Haydon M, Googe J, Meschonat C, Gautreaux M, Williams J, De Benedetti A, Eggerstedt J, Nathan CO, Li B: The Detection of the eukaryotic initiation factor 4E (eIF4E) in Solid Tumors. Proc. Assoc. Academic Surgery, 32: 167, 1998.
    74. Nathan CO, Liu L, Li B, Abreo F, Nandy I, De Benedetti A. Detection of the proto-oncogene eIF-4E in surgical margins may predict recurrence in head and neck cancer. Oncogene, 15: 579-584, 1997.
    75. Nathan CO, Carter P, Liu L, Li B, Abreo F, Tudor A, Zimmer S, De Benedetti A. Elevated expression of eIF-4E and FGF-2 isoforms during vascularization of breast carcinomas. Oncogene, 15: 1087-1095, 1997.
    76. Nathan CO, Seid AB. Neonatal rhinitis - A new approach to a seasonal disease. International Journal of Pediatric Otorhinolaryngology, 39: 59-65, 1997.
    77. Ampil FL, Menezes CO. Glottic Cancer with subglottic extension. Radiation Medicine, 15:103-10724, 1997.
    78. Nathan CO, Liu L., De Benedetti A. The role of eIF4E in neovascularization of head and neck cancers. Otolaryngology/Head and Neck Surgery, 117: 133 1997.
    79. Sorrells DL, Meschonat C, De Benedetti A, Nathan CO, Ghali G, Li BD. Gene Amplification and protein elevation of eIF4E in Head and Neck Squamous Cell Carcinoma. J. Oral Maxillofacial Surgery, 55(8) Supp. 3: 65-66, 1997.
    80.  Ampil FL, Ghali GE, Hardin JC, Hoasjoe D, Aarstad R, Nathan CO, Stucker FJ. Postoperative radiotherapy for head and neck cancer involving carotid artery. Proceedings of the 5th International Congress on Oral Cancer, 34: 97, 1997.
    81. Sorrells D., Ghali G, Nathan CO, De Benedetti A., Meschonat C., DeFatta R., Li, B.D. Detection of eIF4E Gene Amplification in Head and Neck Neoplasms. Proceedings of the Society of Head and Neck Surgeons, 43: 117-118, 1997.
    82. Sorrells, D, De Benedetti A, Nathan CO, Ghali G, Li B: eIF4E and malignant transformation. Proceedings of the Assoc. Academic Surg. 31:173, 1997.
    83. Menezes CO, De Benedetti A, Abreo, F. A survey of the proto-oncogene/translation initiation factor eIF-4E in head and neck squamous cell cancers: Otolaryngology-Head and Neck Surgery, 115:72, 1996.
    84. Ampil FL, Hoasjoe DK, Aarstad RF, Menezes CO, Nickleson RA, Stucker FJ. Supraglottic Laryngeal or Base of tongue cancer involving vallecula. Louisiana State Medical Society, 148: 435-439, 1996.
    85. Menezes CO, Harris JP, Koutnouyan HA., and Ryan A. Absence of mRNA Encoding Estrogen Receptor in the Cochlea of the Rat. Otolaryngology- Head and Neck Surgery, 113: 143, 1995.
    86. Menezes CO, Davidson T. Endoscopic resection of Sphenoid Sinus Osteoma: A Case Report. Ear Nose Throat, 73(8): 598-600, 1994.
    87. Menezes CO, Murry T, Woodson G.: Arytenoid Adduction and Cricopharyngeal Myotomy for Management of Vagal Paralysis. Otolaryngology- Head and Neck Surgery, 107 (2): 219, 1992.
    88. Richtsmeier, W.J., Menezes, C. Direct effects of TNF and the interferons on carcinomas of the head and neck Immunobiology in Otology, Rhinology and Laryngology, Proceedings of the Third International Academic Conference on Immunobiology in Otology, Rhinology and Laryngology; Harris JP, Lim DJ, McCabe BF, Mogi G and Veldman JE(ed), Kugler Publications BV, Amsterdam, 1992.
    89. Menezes CO, Kearns DB, Mair E. Newborn airway obstruction resulting from bilateral congenital nasolacrimal duct cysts. Otolaryngology Head and Neck Surgery, 107 (2): 305, 1992.
    90. Menezes CO, Richtsmeier, W. Properties of a Parotid Derived Mucoepidermoid Carcinoma in Tissue Culture. Otolaryngology- Head and Neck Surgery, 103 (2); 226, 1990.
    91. Menezes CO, Richtsmeier W.J. IFN-gamma Sensitive Head and Neck Derived Squamous Cell Cultures are Insensitive to TNF- alpha. Otolaryngology- Head and Neck Surgery, 101(2): 191, 1989.
    92. Richtsmeier W.J., Menezes CO, Ravenhill G.O., Koch W.M.: Cytolysis in Head and Neck Squamous Cell Carcinoma Inducted by IFN- gamma. Otolaryngology- Head and Neck Surgery, 101 (2): 166, 1989.
    93. Menezes CO, Ryan A: Expression of Five Subunit Isoforms of Na-K-ATPase in the Developmental Rat Cochlea. Otolaryngology- Head and Neck Surgery, 105(2): 191, 1991.
    94. DeSouza C, Menezes CO, DeSouza R, Ogale S, Morris M, Desai A: Profile of Congenital cholesteatomas of the petrous apex. Post-graduate Journal of Medicine, 35(2): 93-97, 1989.
    95. DeSouza C, DeSouza R, Menezes CO, Heiming R, Rosenbaum T, DeSouza S: Mucoceles, Proptosis and Transorbital Frontoethmoidectomy. Orbit, 7(3): 167-173, 1988.
    96. Practical Reviews in Otolaryngology: Selection of the article Nathan CO, Franklin S, Abreo F, Nassar R, De Benedetti A, Glass J. Analysis of Surgical Margins with the Molecular Marker eIF4E: a prognostic factor in patients with Head & Neck Cancer. J Clin Oncol, 17 (9): 2909-2914, 1999.
    97. Journal of The American College of Surgeons Vol. 197 (1): 2003: What’s New in Otolaryngology. Molecular Biology Diagnostics quotes the work on eIF4E in Head and Neck Cancer. 

Submitted for publication

    1. Ampil F, Sangster G, Mills G, Nathan CO, Lian T, Hall A. Radiological Findings after chemoradiation for nasopharyngeal cancer with skull base erosion.
    2. Jiang Ru, Nathan C, Hutt-Fletcher. Laser-capture microdissection of epithelial cells in the oropharynx indicates restriction of expression of Epstein-Barr virus receptor/CD21 mRNA to tonsil epithelium (submitted Journal of Infectious Disease

Abstracts and Posters Presented at Meetings

      1. San Francisco August 2008 (submitted).
      2. Ekshyyan O, Rong J, Rong X, Caldito G, Malhotra K, Chang K, Ampil F, Nathan CO. CCI-779 a promising radiosensitizer for head and neck squamous cell carcinoma when compared to cisplatin. 99th Annual AACR Meeting, San Diego, April 16-20th, 2008 (submitted).
      3. Clark C, McEachern M, Wallace D, Nathan CO. Inhibition of cell growth in HNSCC by curcumin. 99th Annual AACR Meeting, San Diego, April 16-20th, 2008 (submitted).
      4. Cho A, Cotelingam J, Nathan CO. Mucous membrane plasmacytosis of the oral cavity and larynx: two case reports. 201st Combined Otolaryngology Spring Meeting, Orlando FL, 2008. (submitted)
      5. Gill M, Mirfakhree M, Bao J, Nathan CO. Unusual findings in our series of fibrous dysplasia of the paranasal sinuses. 201st Combined Otolaryngology Spring Meeting, Orlando FL, 2008. (submitted)
      6. Malhotra K, Rong Xiaohua, Nathan CO. Correlation of mTOR activation and HIF-1alpha in HNSCC patient samples. 201st Combined Otolaryngology Spring Meeting, Orlando FL, 2008 (submitted)
      7. Gill M, Lian T, Gonzales E, Nathan CO .Cervical thoracic duct cyst:  An uncommon source of left sided neck mass. Southern Section, Jan 10-12, Naples FL, 2008.
      8. Dean M, Maier J, Lilien D, Caldito G, Nathan CO. The effect of PET on the incidence of pulmonary involvement in patients with advanced stage head and neck disease compared to standard chest X-ray Southern Section, Jan 10-12, Naples FL, 2008.
      9. Nathan CO , Sibley D, Rong X, Ekshyyan O, Terry T. Comparison of microPET to Bioluminescence for in vivo imaging of minimal residual disease in HNSCC. Federation of European Biocehmistry Society, Austria, July 2007.
      10. Nathan CO, Dixon C. Microarray analysis of curcumin in head and neck squamous cell cancer. Annual Meeting of the American Academy of Otolaryngology Head and Neck Surgery Foundation, Washington D.C., Sept 2007.
      11. Ampil F, Nathan CO, Caldito G, Nanda A, Lian T. Combined therapy for skull base invasion of head and neck cancer: review of a 24 year experience. NASB, Chicago May 2007.
      12. Nathan CO, Mills G, Rong X, Drummond D, Amirghahari N, Agarwal A, Rong Y, Glass J, Lian T. An Exploratory biomarker trial of mTOR inhibitors in subjects with newly diagnosed advanced stage squamous cell carcinoma of the head and neck. 98th Annual AACR Meeting, LA, April14-16, 2007
      13. Nathan CO, Nordberg M, Martin S, Amirghahari N. PTEN abnormalities in head and neck tumors and margins detected by FISH. AACR LA, April 14-16, 2007.
      14. Dean M, Gonzales E, Nathan CO.  The preoperative importance of considering Cervical Sympathetic Chain Schwannoma. Triological Society Meeting, San Diego, April 26-29, 2007.
      15. Ilabachie K, Morgan M, Ampil F, Nathan CO. Return of vocal cord movement: an independent predictor of response to non-surgical management of laryngeal cancers. Southern Section Naples FL, Feb 16-19the 2007.
      16. Ampil F, Nathan CO, Caldito G, Nanda A, Lian T. Combined therapy for skull base invasion of head and neck cancer: 24 year experience. Central Nervous System Malignancies Congress, Warsaw, Poland March 30 - 31, 2007.
      17. Ampil F, Nathan CO, Lian T. Total laryngectomy and T3-T4 laryngeal cancer without other adverse histopathology: after-management, risk of relapse, and prognosis. International Meeting on Innovative Approaches in Head and Neck Oncology, Barcelona, February 22-24, 2007.
      18. Goodier M, Takalkar A, Lilien D, Kupferman T, Lian T, Nathan CO. Utility of Panendoscopy for Unknown Primary and Negative PET. AAO-HNS, Toronto Sep 2006.
      19. Malhotra K, Morgan M, Armstrong C, Nathan CO. Laryngopharyngeal reflux as a cause of TEP failure. American Laryngological Society, Chicago IL, May 19-20, 2006.
      20. Nathan CO, Amirghahari N, Rong X, Giordano A, Sibley D, Sunderland J. Comparison of microPET to Bioluminescence for In Vivo Imaging of Minimal Residual Disease in HNSCC. 109th Combined Otolaryngology Spring Meeting, Chicago IL, May 21-22nd, 2006.
      21. Gurley M, Lowery Nordberg M, Shackelford R, Katz S, Ampil F, Nathan CO. Radiation sensitivity testing in a patient with chromosomal instability syndrome. Southern Section Triologic, Naples FL, Jan 14-16, 2006.
      22. Malhotra K, Nathan CO. A Unique case of a sublingual space schwannoma. Southern Section Triologic, Naples FL, Jan 14-16, 2006.
      23. Malhotra K, Nanda A, Nathan CO. Facial reanimation using hypoglossal-facial jump interpositional graft. North American Skull Base 17th Annual Meeting, Phoenix AZ, Feb 16-19, 2006.
      24. Malhotra K, Stucker F, Lian T, Nathan CO. Periorbital necrotizing fasciitis: Importance of determining the source. Southern Section Naples Florida , Jan 12-14, 2006
      25. Gurley M, Lowery Nordberg M, Shackelford R, Katz S, Ampil F, Nathan CO. Radiosensitivity testing in a patient with chromosomal instability syndrome. Southern Section Naples Florida, Jan 12-14, 2006.
      26. Nathan CO, Amirghahari N, Rong X, Sibley D, Giordano A. Bioluminescence Tracks the in vivo effects of CCI-779 in a Minimal Residual Disease Model of HNSCC. 97th Annual AACR Meeting, April 2-5, 2006.
      27. McDuffie C, Morgan M, Armstrong C, Nathan CO. Electrical Stimulation in Post-Irradiated Head and Neck SCCA. AAO-HNS, Los Angeles Sept 2005.
      28. Nathan CO, Amirghahari N, Rong X, Yun S. Inhibiting the mTOR pathway with CCI-779 results in decreased production of Vascular Endothelial Growth Factor. FEBS-IUBMB 2005 Conference, Budapest July 2005.
      29. Chakradeo V, Malhotra K, Lee M, Nathan CO. Computer Navigational Surgery with Voice - controlled Robotic assist for endoscopic transnasal hypophysectomy. AAO-HNS, Los Angeles 2005.
      30. Nathan CO, Chakradeo V, Malhotra K.  Voice controlled robotic assist for Endoscopic approach to the pituitary. North American Skull Base Society, Toronto, April 2005.
      31. Amirghahari N, Sibley D, Rong X, Caldito G, Nathan CO. Growth Inhibitory and pharmacodynamic effects of CCI-779, an mTOR inhibitor, in a preclinical microscopic residual disease model of head and neck squamous carcinoma. AACR, Anaheim, April 2005.
      32. Nathan A, Turakhia A, Amirghahari N, Nathan CO, Klimstra W, Katherine R. Sindbis Virus as a Novel Oncolytic Vector for Virotherapy of Head and Neck Cancer. AAO-HNS, Los Angeles, 2005.
      33. McDuffie C, Amirghahari N, Caldito G, Thompson L, Lian T, Nathan CO. Predictive Factors for Posterior Triangle Metastasis: A Retrospective Review. Southern Section Triologic, Florida, Jan 13-15, 2005.
      34. Gurley M, Nathan CO. Malignant degeneration of recurrent respiratory papillomatosis: a case report and review of the literature. Southern Section Triologic Florida, Jan 13-15, 2005.
      35. Nathan CO, Amirghahari N, Rong Xiaohua R, Huijuan Z, Harrison L. eIF4E overexpression may confer radioresistance in a head and neck cancer cell line. Annual Meeting of the American Academy of Otolaryngology Head and Neck Surgery Foundation, NY, Sept 19-22, 2004
      36. Ampil F, Caldito G, Hardin J, Krishnamsetty R, Nathan CO. Surgery and post-operative radiotherapy for head and neck cancer with bone or cartilage invasion. 6th International Head and Neck Conference, Washington DC, August, 7-11th, 2004.
      37. Ampil F, Caldito G, Hardin J, Krishnamsetty R, Nathan CO. Successful chemoradiation for head and neck cancer with trismus or prevertebral fascia involvement. 6th International Head and Neck Conference, Washington DC, August, 7-11th, 2004.
      38. Lee M, Nathan CO: False positive PET scan findings in Vocal Cord Paralysis, Southern Section, Triologic, Jan 24th 2004.
      39. Thibodeaux J, Nathan CO. Bilateral Vocal Cord Paralysis in Parkinson’s patients, Southern Section, Triologic, Jan 25th 2004.
      40. Nathan CO, Amirghahari N, Abreo F, Shi R, Caldito G, Gurley M, Lusk J, Stucker F. Long Term Follow-Up of a Large Prospective Trial Indicates that Molecular Analysis of Surgical Margins with eIF4E Predicts Outcome in HNSCC patients with Node - Negative Disease. 6th International Conference on Head and Neck Cancer, Washington DC, August, 7-11th, 2004.
      41. Amirghahari N, Sibley D, Rong X, Khodavandi M, Zhou H, Smith MB, Nathan CO. In vivo and in vitro effect of CCI-779 a rapamycin analogue on HNSCC. 95th Annual AACR Meeting, Orlando, Florida, March 30th, 2004.
      42. Moody CA, Amirghahari N, Scott RS, Nathan CO, Sixbey JW. The effect of LMP2A expression on the mTOR pathway: A potential mechanism by which EBV promotes tumor progression. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, proceeding, pg 43, 2004.
      43. Donnellan K, Jones LM, Amirghahari N, Abreo F, Caldito G, Nathan CO: Correlation of Phospho-mTOR (Ser2448) and AKT with the proto-oncogene eIF4E in HNSCC patients. Louisiana Chapter American College of Surgeons, New Orleans, Louisiana, 2004.
      44. Donnellan K, Nathan CO, Jones ML, Amirghahari N, Abreo F, Caldito G, Zhou H: Correlation of Phospho-mTOR (Ser2448) with the proto-oncogene eIF4E in HNSCC patients. American Federation for Medical Research, Southern Regional Meeting, New Orleans, Louisiana, 2004.
      45. Nathan CO, Amirghahari N, Sibley D: Phospho-mTOR activation in HNSCC maybe induced by Akt. 107th Annual Meeting at COSM, Phoenix, Arizona, 2004.
      46. Amirghahari N, Smith M, Rong X, Shi R, De Benedetti A, Nathan CO: Correlation of mTOR activation in head and neck cancer patients with eIF4E positive margins. 94th Annual Meeting AACR, Washington, DC, 2003.
      47. Smith M, Amirghahari N, Rong X, Nathan CO: Anti-tumor effects of rapamycin in head and neck cancer, The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, proceeding pg, 12, 2003.
      48. Naumann I, Amirghahari N, Rong X, Shi R, Nathan CO: COX-2 inhibitors and effects on COX-2 protein after radiation. VII, Symposium on Head and Neck Cancer in Düsseldorf, 2003.
      49. Nathan CO, Amirghahari N, Smith M, Rong X: Growth inhibitory effects of rapamycin on oral cavity squamous cell carcinoma. Otolaryngology-Head and Neck Surgery, Orlando, Florida, 2003.
      50. Amirghahari N, Smith M, Rong X, Abreo F, Jones LM, Shi R, Nathan CO: mTOR activation in head and neck cancer. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 2003.
      51. Smith M, Amirghahari N, Rong X, Nathan CO: Anti-tumor effects of rapamycin in head and neck cancer, The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 2003.
      52. Pham J, Yin S, Morgan M, Stucker F, Nathan CO: Vocal-fold granulomas: botulinum toxin maybe first line of treatment. Southern Section Meeting, Naples, Florida, 2003.
      53. Rice C, Stucker F, Nathan CO: Endoscopic management of complex frontal sinus mucosal: A safe approach with image guidance. Southern Section Meeting, Naples, Florida, 2003.
      54. Nathan CO, Department of Otolaryngology/HNS: Chemoprevention in Head and Neck Cancer, Shreveport, Louisiana, March 2003.
      55. Nathan CO, Department of Hematology/Oncology: mTOR inhibitors as adjuvant therapy for head and neck cancer patients, Shreveport, Louisiana, June 2003.
      56. Nathan CO, Department of Otolaryngology/HNS: Adjuvant Therapy for Minimal Residual Disease, Shreveport, Louisiana, October 2003.
      57. Stucker F, Nathan CO, Lian T: Management experience in 142 cases of rhinophyma. IFOS World Congress, Cairo Egypt, 2002.
      58. Stucker F, Nathan CO, Lian T: The use of autogenous cartilage grafts in revision nasal surgery. IFOS World Congress, Cairo Egypt, 2002.
      59. Nathan CO, Dixie L, Stucker F: Voice-controlled robotic assist for endoscopic sinus surgery. American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, San Diego, California, 2002.
      60. Amirghahari N, Smith M, Rong X, Glass J, Stucker F, Nathan CO: Upregulation of COX-2 protein induced by radiation is inhibited by COX-2 inhibitor NS398 and appears to be post-transcriptional. Sixth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, McLean, Virginia, 2002.
      61. Beal M, Chesson A, Garcia T, Stucker F, Nathan CO: Quantitative aspiration during sleep in patients suspected of suffering from obstructive sleep apnea. Eastern Section of the American Laryngological, Rhinological and Otological Society, Inc., Philadelphia, PA, 2002.
      62. Amirghahari N, Rong X, Naumann I, Ampil F, Shi R, Glass J, Harrison L, Nathan CO: Radiosensitizing and growth inhibition of a HNSCC cell line by a COX-2 inhibitor, NS398. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 2002.
      63. Goldfarb P, Biel M, Sayed-El, Hanna E, Hier M, Houck J, Klotch D, Nathan CO, Panje W, Robbins T, Shaw G, Jones V, Nassar J, Rice D, Vieira F: Treatment of recurrent head and neck cancer utilizing electroporation with intralesional bleomycin: Long term survival. 39th ASCO Annual Meeting, Chicago, Illinois, 2002.
      64. Nathan CO, Amirghahari N, Rong X, Naumann I, Ampil F, Shi R, Glass J, Harrison L: Radiosensitizing and growth inhibition of a HNSCC cell line by a COX-2 inhibitor, NS398. 93rd Annual AACR Meeting, San Francisco, California, 2002.
      65. Karen M, Nathan CO, Stucker F: Use of perichondrial cutaneous grafts in head and neck reconstruction. Combined Otolaryngology Spring Meeting; Palm Springs California, 2001.
      66. Ampil FL, Nathan CO, Stucker F: Use of Perichondrial cutaneous grafts in head and neck reconstruction. Combined Otolaryngology Spring Meeting, Palm Springs California, 2001.
      67. Ampil FL, Nathan CO, Mulcahy G, Caldito G, Stucker F, Aarstad RF, Lian TS: Is total laryngectomy alone enough in patients with T3N0M0 glottic cancer? Review of a 17-year experience, Southern Medical Society, New Orleans, 2001.
      68. Ampil FL, Mills G, Burton G, Caldito G, Nathan CO, Stucker F, Aarstad RF, Lian TS, Hardon JC: Chemoradiation-induced regression of advanced cervical lymphadeopathy in head and neck cancer as a predictor of outcome. 8th Hong Kong International Cancer Congress 6th Research postgraduate symposium, HKU, 2001.
      69. Lian TS, Karen M, Nathan CO, Stucker F: Use of perichondral cutaneous grafts in eyelid reconstruction of children. American Society of Pediatric Otolaryngology (ASPO), Scottsdale, Arizona, 2001.
      70. Chandy B, Todd J, Stucker F, Lal C, Nathan CO: Pott’s puffy tumor and epidural abscess arising from dental sepsis: a case report. Southern Section Triologic Meeting, Marco Island, Florida, 2001.
      71. Burton G, Ampil FL, Mills G, Nathan CO, Gamage C: Nasopharyngeal cancer: multidisciplinary therapy with cisplatin, 5-fluorouracil, etopside and radiotherapy.  10th International Congress on Anticancer Treatment, Paris, France, 2000.
      72.  McCaffrey J, Nathan CO, Levine P, Burkey B, Reiber M, Parke R, Hart J, Urken M, Stack B, Parey S, Shyr Y, Tarr C, Stawiasz, Lore J, Goldstein J, Sisson G, Day T: Head and neck cancer screening: a multi-institutional effort. 5th International Conference on Head and Neck Cancer, San Francisco, California, 2000.
      73. Ampil FL, Mills G, Caldito G, Nathan CO, Stucker F: Induction chemotherapy followed by concomitant chemoradiation for cervical lymphadenopathy. 2nd International Chicago Symposium on Malignancies of the Chest and Head and Neck, Chicago, Illinois, 2000.
      74. DeFatta R, Nathan CO, De Benedetti A: Reducing the level of eIF4E with antisense RNA suppresses the oncogenic properties of head and neck squamous cell carcinoma cell line. Combined Otolaryngology Spring Meetings, Orlando, Florida, 2000.
      75. Nathan CO, Leskov I, Abreo F, Shi R, Stucker F: Correlating the expression of eIF4E and COX-2 in head and neck tumorigenesis. 5th International Conference on Head and Neck Cancer, San Francisco, California, 2000.
      76. Yin SP, Pate W, Nathan CO, Driscoll P, Watkings W, Batchelor B, Stucker F: Diagnosis and treatment of immobile vocal fold after thyroid tumor surgery: laryngeal joint origin. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 2000.
      77. Nathan CO, Leskov I, Abreo F, Shi R, Stucker F: Correlating the expression of eIF4E and COX-2 in head and neck tumorigenesis. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 2000.
      78. Rice C, Abreo F, Shi R, Leskov I, Stucker F, Nathan CO: A strong correlation exists between matrix metalloproteinase-9 and eIF4E in squamous cell carcinoma of the head and neck. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 2000.
      79. Rice C, Abreo F, Shi R, Leskov I, Stucker F, Nathan CO: Expression of matrix metalloproteinase-9 and eIF4E co-localize in squamous cell carcinoma of the head and neck. American Academy of Otolaryngology/HNS, Washington, DC, 2000.
      80. Price K, Sanusi I, Stucker F, Nathan CO: Metastatic malignant fibrohistiocytoma of the parotid: a case report. Southern Medical Society, 2000 (3rd Place Resident Award).
      81. Sanders K, Abreo F, Rivera E, Stucker F, Nathan CO: A diagnostic and therapeutic approach to paragangliomas of the larynx. Western Section Triologic Meeting, San Francisco, California, 2000.
      82. Borski G, Aarstad R, Stucker F, Nathan CO: Plasma cell neoplasms of the sphenoid sinus: a diagnostic and treatment dilemma. Western Section Triologic Meeting, San Francisco, California, 2000.
      83. Chandy B, Abreo F, Nassar R, Stucker F, Nathan CO: Expression of the proto-oncogene eIF4E in dysplasia: a potential biomarker. Southern Section Triologic Meeting, Petersburg, Florida, 2000.
      84. Sanders K, Franklin S, Abreo F, Nassar R, Stucker F, Nathan CO: Correlation of p53 and the proto-oncogene eIF4E in larynx cancers. 85th Clinical Congress of the American College of Surgeons, San Francisco, California, 1999.
      85. Ampil FL, Mills G, Nathan CO, Stucker F, Chin HW: Radical combined treatment for locally extensive head and neck cancer in the elderly: 90th Annual Meeting AACR, Philadelphia, PA, 1999.
      86. Goldfarb P, Biel M, Hanna E, Houck J, Klotch D, Nathan CO, Panje W, Robbins T, Shaw G, El-Sayed S, Hier M, Jones V, Nassar J, Rice D: A phase II study using electroporation and intratumoral bleomycin in patients with recurrent head and neck cancer. A safe and active treatment approach. 35th Annual Meeting ASCO, Atlanta, Georgia, 1999.
      87. Franklin S, Abreo F, Nassar R, De Benedetti A, Williams J, Stucker F, Nathan CO: Expression of eIF4E during head and neck Tumorigenesis: possible role in angiogenesis.  Triological Society Southern Section Meeting, New Orleans, Louisiana, 1999. (Award for Best Paper).
      88. Nathan CO, Yin S, Stucker F: Botulinum Toxin: Adjunctive treatment for posterior glottic synechiae.  Triological Society Southern Section Meeting, New Orleans, Louisiana, 1999.
      89. Borski G, Stucker F, Nathan CO: Leiomyoma of the trachea: A new approach. Triological Society Southern Section Meeting, New Orleans, Louisiana, 1999.
      90. Sanders K, Pate W, Fowler M, Stucker F, Nathan CO: Aggressive fibromatosis of the parapharyngeal space. Southern Medical Society Annual Meeting, Dallas, Texas, 1998. (3rd Place Award).
      91. DeFatta R, Gan W, De Benedetti A, Rhoads R, Franklin S, Abreo F, Stucker F, Nathan CO: Using the eukaryotic translation initiation factor eIF4G as a diagnostic and prognostic tool to identify HNSCC. Southern Medical Society Annual Meeting, 1998. (2nd Place Award).
      92. Nathan CO, Franklin S, Abreo F, Nassar R: Immunohistochemical detection of the proto-oncogene eIF4E in surgical margins of head and neck cancer patients may predict recurrence. 4th International Symposium of Predictive Oncology and Therapy, Nice France, 1998.
      93. Nathan CO, Frankslin S, Abreo F, Stucker F: A molecular analysis of surgical margins using eIF4E in head and neck squamous cell cancers. American Academy of Otolaryngology-Head and Neck Surgery, Oakland, California.
      94. Gan W, DeFatta R, De Benedetti A, Nathan CO, Rhodas R: The eukaryotic translation initiation factors eIF4G and eIF4E are coregulated in tumor cell lines and cell over – or underexpressing eIF4E. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 1998.
      95. Franklin S, Pho T, Abreo F, Nasser R, De Benedetti A, Stucker F, Nathan CO: Immunohistochemical detection of the proto-oncogene eIF4E in larynx and hypopharynx cancers. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 1998.
      96. DeFatta R, De Benedetti A, Nathan CO, Li B, Williams, BJ: The role of eIF-4E in vascularization and progression of breast cancer. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 1998.
      97. Nathan CO, Liu L, De Benedetti A: The role of eIF4E in neovascularization of head and neck cancers. American Academy of Otolaryngology/Head and Neck Surgery, San Francisco, California, proceeding: OTO/HNS 117, 1997.
      98. Sorrells DL, Meschonat C, De Benedetti A, Nathan CO, Ghali G, Li BD: Gene amplification and protein elevation of eIF4E in head and neck squamous cell carcinoma. American Academy of Oral Maxillofacial Surgery, 1997.
      99. Ampil FL, Ghali G, Hardin JC, Hoasjoe D, Aarstad RF, Nathan CO, Stucker F: Postoperative radiotherapy for head and neck cancer involving carotid artery. 5th International Congress on Oral Cancer, London, UK, 1997.
      100. Sorrells DL, Ghali G, Nathan CO, De Bendetti Al, Meschonat C, DeFatta R, Li BD: Detection of eIF4E gene amplification in head and neck neoplasms. Proceedings of the American Society of Head and Neck Surgeons, Toronto, Canada, 1997.
      101. Nathan CO, Li L, Li B, Abreo F, De Benedetti A: Detection of the eIF4E oncoprotein at the surgical margins of squamous cell cancers of head and neck. The Ray A. Barlow Scientific Symposium, Shreveport, Louisiana, 1997.
      102. Sorrells DL, Ghali GE, Meschonat CJ, DeFatta R, Nathan CO, De Benedetti A, Li B: Detection of eIF4E gene amplification in head and neck neoplasms. The Ray A. Barlow Scientific Symposium, proceeding, Shreveport, Louisiana, 1997.
      103. Menezes CO, De Benedetti A, Abreo F: A survey of the proto-oncogene eIF4E in head and neck squamous cell cancers. American Academy of Otolaryngology/Head and Neck Surgery, Washington, DC, 1996.
      104. Menezes CO, Seid AB: Neonatal rhinitis – A new approach to a seasonal disease. American Society of Pediatric Otolangology, Durango, Colorado, 1995.
      105. Menezes CO, Harris JP, Koutnouyan HA, Ryan A: Absence of mRNA encoding estrogen receptor in the cochlea of the rat. American Academy of Otolaryngology/Head and Neck Surgery, New Orleans, Louisiana, 1995.
      106. Harris JP, Kuppersmith RB, Menezes CO: Exogenous reproductive hormone as a etiology of meniere’s syndrome. American Neurotology Society Annual Spring Meeting, Scottsdale, Arizona, 1993.
      107. Menezes CO, Ryan A: Expression of five subunit isoforms of Na-K-ATPase in the development rat cochlea. American academy of Otolaryngology/Head and Neck Surgery, Washington, DC, 1992.
      108. Menezes CO, Murry T, Woodson GE: Arytenoid adduction and cricopharyngeal myotomy for management of vagal paralysis. American Academy of Otolaryngology/Head and Neck Surgery, Washington, DC, 1992.
      109. Menezes CO, Mail E, Kearns DB, Pransky S, Seid AB: Development of a new stent for choanal atresia. American Society for pediatric Otolaryngology, Palm Spring, California, 1992.
      110. Richtsmeier WJ, Menezes CO, Harris JP, Lim DJ, McCabe BF, Mogi G, Veldman JE: Direct effects of TNS and the interferons on carcinomas of the head and neck immunobiology in otology, rhinology and larngology, proceedings of the 3rd International Academic Conference on Immunobioogy in Otology, Rhinology and Larngology, Kugler Publications BV, Amsterdam, 1992.
      111. Menezes CO, Kearns DB, Mair E: A case report on bilateral congenital nasolacrimal duct cyst obstruction. American Academy of Otolaryngology Head and Neck surgery, Washington, DC, 1992.
      112. Menezes CO, Richtsmeier WJ: IFN-gamma sensitive head and neck derived squamous cell cultures are insensitive to TNF-alpha. Academy of Otolaryngology/Head and Neck Surgery Research Forum, New Orleans, Louisiana, 1989.
      113. Richtsmeier WJ, Menezes CO, Ravenhill GO, Koch WM: Cytolysis in head and neck squamous cell carcinoma inducted by IFN-gamma. American Academy of Otolaryngology/Head and Neck Surgery Research Forum, New Orleans, Louisiana, 1989.
      114. Menezes CO, Richtsmeier WJ: Properties of a parotid derived mucoepidermoid carcinoma in tissue culture. American Academy of Otolaryngology/Head and Neck Surgery, Washington, DC, 1988.